The 3D Genome Structure of a <i>Blcap</i> -Linked Silencer Loop Regulates Terminal Differentiation During Lens Fiber Cell Denucleation
The Blcap-DSR chromatin loop plays a key protective role by repressing Blcap and maintaining anti-apoptotic balance in LFCs. Through silencer-associated looping and epigenetic reprogramming, LFCs achieve controlled nuclear and organelle clearance without triggering cell death, ensuring proper differentiation and lens transparency.
Authors
- Yingfeng Zheng (ORCID: https://orcid.org/0000-0002-0914-7864)
- Zhong Liu (ORCID: https://orcid.org/0000-0003-3067-1967)
- Lixia Luo (ORCID: https://orcid.org/0000-0002-9806-4074)
- Shurui Ke
- Jingyu Ma (ORCID: https://orcid.org/0000-0002-5524-6353)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1167/iovs.66.15.26
- Citations
- 1
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Guangdong Province