Calpain-1 Potentiates Periodontal Regeneration via PHLPP1-ERK-Driven Osteogenesis in Periodontal Ligament Stem Cells
Our study reveals the role and mechanism of CAPN1 in the osteogenic differentiation of hPDLSCs, which provides a theoretical and technical foundation for targeting CAPN1 in bone regeneration.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0002-6810-9585)
- Yuejia Li (ORCID: https://orcid.org/0009-0009-5972-1893)
- Jie Li (ORCID: https://orcid.org/0000-0003-2343-1658)
- Pingmeng Deng
- Ziyi Mei
- Tiwei Fu
Institutions
- Stomatological Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.identj.2025.109309
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00