Associations between composite systemic inflammation indicators(CAR, CLR, SII, AISI, SIRI, and CALLY) and metabolic dysfunction-associated fatty liver disease (MAFLD): evidence from a two-stage study in China

Systemic immune-inflammatory indices exhibit nonlinear associations with MAFLD risk, independent of traditional metabolic factors. This reinforces MAFLD as a systemic inflammatory disease and highlights the potential of anti-inflammatory strategies, especially during the early, reversible stage before the risk plateaus.