Apolipoprotein C1 -317H1/H2 and the rs4420638 genetic variations and risk of gestational diabetes mellitus in Chinese women: a case-control study
ApoC1 gene polymorphisms associate with GDM risk and affect the lipid profile. The combined H1H1/AG+GG genotype of the apoC1 gene polymorphisms appears to augment the propensity to develop GDM, while the rs4420638 polymorphism links to adverse lipid components in the patients. Further genetic studies to add information beyond the traditional risk factors in GDM and to identify risk genotypes will help in early prediction and identification of at-risk patients.
Authors
- Linbo Guan (ORCID: https://orcid.org/0000-0003-1479-5388)
- Huai Bai (ORCID: https://orcid.org/0000-0002-6635-021X)
- Ping Fan (ORCID: https://orcid.org/0000-0003-1167-5858)
- Xinghui Liu (ORCID: https://orcid.org/0000-0001-7366-0825)
- Yujie Wu (ORCID: https://orcid.org/0000-0002-2906-9998)
- Yuwen Guo (ORCID: https://orcid.org/0000-0002-0576-5657)
- Zhengting Zhu
- Wandi Ma
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-21
- DOI
- https://doi.org/10.3389/fendo.2025.1681268
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and Innovative Research Team in University