Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
The dualistic roles of HMGB1 in cancer and inflammation highlight its complexity and potential as a therapeutic target. Future research should focus on elucidating the context-specific mechanisms of HMGB1, developing precision-targeted therapies to modulate its multifunctional activities, and translating these findings into clinical practice to improve patient outcomes.
Authors
- Xiaohong Du (ORCID: https://orcid.org/0000-0002-1387-524X)
- Leifeng Chen (ORCID: https://orcid.org/0000-0001-8305-1900)
- Zuao Wang
- Xu Zhang (ORCID: https://orcid.org/0009-0004-9921-9586)
- Yujia Jiang
- Yuxiang Luo
- Wen Zeng (ORCID: https://orcid.org/0009-0002-7884-2964)
Institutions
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cam4.71455
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Natural Science Foundation of China
- Jiangxi Provincial Department of Science and Technology