Distinct Natural Killer Cell Signature in Still Disease: Insights From a Multinational Immunome Project Consortium for Autoinflammatory Disorders
Our findings establish NK cell apoptosis, exhaustion, and cytokine unresponsiveness as defining immunologic features of Still disease, distinguishing it from other inflammatory diseases in this cohort. This dysfunctional NK cell state may underlie the heightened risk of macrophage activation syndrome in Still disease and highlights inflammatory cytokines and miR-146a as promising therapeutic targets to mitigate disease severity and prevent life-threatening complications.
Authors
- Carine Wouters
- Harmen J.G. van de Werken (ORCID: https://orcid.org/0000-0002-9794-1477)
- Yvonne M. Mueller (ORCID: https://orcid.org/0000-0002-4654-7509)
- Nele Berghmans (ORCID: https://orcid.org/0009-0003-9217-6459)
- Stéphanie Humblet‐Baron (ORCID: https://orcid.org/0000-0003-4684-069X)
- Kourosh Ahmadzadeh
- Paul Régnier (ORCID: https://orcid.org/0000-0002-9713-1132)
- Cem Gabay (ORCID: https://orcid.org/0000-0001-6853-3063)
- Dwin G.B. Grashof (ORCID: https://orcid.org/0000-0002-4169-9888)
- Peter D. Katsikis (ORCID: https://orcid.org/0000-0001-7690-5218)
- Eline Bernaerts (ORCID: https://orcid.org/0000-0002-7998-4553)
- Katerina Laskari (ORCID: https://orcid.org/0000-0002-6477-6583)
- Jessica Filtjens
- Mieke Gouwy (ORCID: https://orcid.org/0000-0002-4035-4810)
- Bert Malengier‐Devlies (ORCID: https://orcid.org/0000-0003-3527-1145)
- Yvan Jamilloux (ORCID: https://orcid.org/0000-0001-5249-3650)
- Paul Proost (ORCID: https://orcid.org/0000-0002-0133-5545)
- Patrick Matthys (ORCID: https://orcid.org/0000-0002-9685-6836)
- Jarne Beliën (ORCID: https://orcid.org/0000-0001-6731-6649)
- Tania Mitera
- Amber De Visscher (ORCID: https://orcid.org/0000-0002-9577-2390)
- Charlotte Girard (ORCID: https://orcid.org/0000-0002-4901-2059)
- David Saadoun (ORCID: https://orcid.org/0000-0003-3628-9996)
- Leana De Vuyst
- Stefan J. Erkland
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Allen Institute for Brain Science (US)
- Inserm (FR)
- Rega Institute for Medical Research (BE)
- Erasmus MC (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Référence des Maladies Autoinflammatoires et des Amyloses (FR)
- Hospices Civils de Lyon (FR)
- University Hospital of Geneva (CH)
- Pitié-Salpêtrière Hospital (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Geneva College (US)
- Athens State University (US)
- KU Leuven (BE)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1002/art.70008
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00