In vitro Multi-targeted Anti-cancer Effects of Bavachinin in Papillary Thyroid Carcinoma Cell Line: Dual Pathway Inhibition and Cytokine Downregulation
Bavachinin exerts multi-targeted anti-cancer effects in thyroid carcinoma cells through dual inhibition of the phosphoinositide-3-kinase (PI3K)/AKT/mTOR and mitogen-activated protein kinase (MAPK)/ERK pathways, along with suppression of pro-inflammatory cytokines, culminating in apoptosis and impaired invasiveness.
Authors
- Yuan Tian (ORCID: https://orcid.org/0000-0002-2296-1246)
- Zahra Zahid Piracha (ORCID: https://orcid.org/0000-0001-8973-9773)
- Usman Saeed (ORCID: https://orcid.org/0000-0002-2380-7881)
- Gang Duan
Institutions
- Cyprus International University (CY)
- Riphah International University (PK)
- Korea University (KR)
- Institute of Endemic Disease Control in Shandong Province (CN)
- Korea University (JP)
- Széchenyi István University (HU)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-11-27
- DOI
- https://doi.org/10.5812/ijpr-166894
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00