An ROS/viscosity dual-activated nanoprobe with CD44-targeting ability for NIR-II imaging of early atherosclerotic plaques
We developed a NIR-II fluorescent nanoprobe, DCy-BOH@BSA-HA, for targeted identification of atherosclerotic (AS) plaques. The probe remains quiescent initially but is dually activated by the plaque microenvironment-specifically elevated ROS and viscosity-while (hyaluronic acid) HA mediates CD44 targeting. This strategy enabled precise NIR-II fluorescence imaging of aortic plaques in a murine AS model.
Authors
- Jun Nie
- Shuai Zhao (ORCID: https://orcid.org/0000-0003-4219-1944)
- Wenjing Wang (ORCID: https://orcid.org/0000-0001-6025-9848)
- Jingang Zheng (ORCID: https://orcid.org/0000-0002-3769-6166)
- Ruixin Liu (ORCID: https://orcid.org/0000-0002-5526-6717)
- Yike Li (ORCID: https://orcid.org/0000-0003-1971-2318)
- Yincheng Chang (ORCID: https://orcid.org/0000-0003-3519-9876)
- Fang Sun (ORCID: https://orcid.org/0000-0003-4064-1921)
- Yanxiang Gao (ORCID: https://orcid.org/0000-0003-2331-5956)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1039/d5cc05890b
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 0.00