Effectiveness of slow-release oral morphine versus other OAT regimens in key sub-populations: protocol for population-based target trial emulation
This study will generate real-world evidence on the comparative effectiveness of SROM versus methadone and buprenorphine/naloxone across clinically distinct OAT sub-populations. The findings will support evidence-informed updates to OAT guidelines and clinical decision-making in BC and other jurisdictions facing escalating opioid-related harms.
Authors
- Paxton Bach (ORCID: https://orcid.org/0000-0002-2413-9133)
- Sander Greenland (ORCID: https://orcid.org/0000-0003-4364-3279)
- Jeong Eun Min
- Michelle Zanette
- Momenul Haque Mondol (ORCID: https://orcid.org/0000-0002-2624-2118)
- M. Eugenia Socías (ORCID: https://orcid.org/0000-0003-2556-7049)
- Paul Gustafson
- Shaun R. Seaman (ORCID: https://orcid.org/0000-0003-3726-5937)
- Bohdan Nosyk (ORCID: https://orcid.org/0000-0003-2513-3718)
- Robert W. Platt (ORCID: https://orcid.org/0000-0002-5981-8443)
Institutions
- University of British Columbia (CA)
- University of California, Los Angeles (US)
- Simon Fraser University (CA)
- University of Barishal (BD)
- British Columbia Centre on Substance Use (CA)
- MRC Biostatistics Unit (GB)
- Centre for Advancing Health Outcomes (CA)
- McGill University (CA)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-03
- DOI
- https://doi.org/10.64898/2025.11.30.25341316
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse