Extracellular vesicle miR-425-5p promotes visceral fat reduction via DACT1 suppression in SGLT2i-treated diabetes
Plasma-derived EV miR-425-5p, increased by long-term SGLT2i therapy in T2D patients, may inhibit adipocyte differentiation and lipogenesis via DACT1 suppression. These findings suggest a possible mechanistic link through which SGLT2i treatment may ameliorate visceral obesity.
Authors
- Gyeong Im Yu (ORCID: https://orcid.org/0000-0003-1494-3977)
- Jae‐Hyung Park (ORCID: https://orcid.org/0000-0002-3549-5977)
- Yun‐Ui Bae (ORCID: https://orcid.org/0000-0002-5084-5293)
- Eun Yeong Ha (ORCID: https://orcid.org/0000-0002-9534-4329)
- Ho‐Chan Cho (ORCID: https://orcid.org/0000-0003-0712-7728)
- Hye Min Shim
- Junho Kang
- Thi Tuyet Nhung Nguyen (ORCID: https://orcid.org/0000-0002-4441-2862)
Institutions
- Keimyung University Dongsan Medical Center (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fendo.2025.1725625
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Education, Science and Technology
- Ministry of Science and ICT, South Korea