T cell immunometabolic dysfunction in a mouse model of cecal ligation and puncture-induced sepsis
Our findings provide several layers of T cell dysfunction in sepsis, linking subset redistribution, an exhausted phenotype, mitochondrial impairment, and reduced proliferative capacity, suggesting that future therapeutic interventions aiming to reverse sepsis-induced immunosuppression may require a combinatorial approach.
Authors
- Xiaoju Liu (ORCID: https://orcid.org/0009-0000-2795-0186)
- Zhong Chen (ORCID: https://orcid.org/0000-0002-9644-1737)
- Zhijian Yu
- Peiyu Li
- Mai Liting
Institutions
- Shenzhen Sixth People's Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- Anshan Hospital (CN)
Publication Details
- Journal
- BMC Immunology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12865-025-00790-9
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.80