Antipsychotic Treatment-Associated Modulation of ABC Transporter Genes (ABCC1, ABCB1, and ABCA2) in Schizophrenia: A Longitudinal Expression Study
These findings demonstrate distinct, gene-specific alterations in ABC transporter expression in schizophrenia. ABCC1 and ABCB1 appear suppressed during acute illness and partially restored with antipsychotic therapy, while ABCA2 shows a strong treatment-related upregulation. ABC transporter expression-particularly ABCB1-may provide preliminary molecular insight into treatment-related variability, although biomarker utility cannot be established from the present data. Longitudinal pharmacogenomic studies are needed to clarify their clinical relevance.
Authors
- Filiz Ekim Çevik (ORCID: https://orcid.org/0000-0002-1262-6452)
- Murat Erkıran (ORCID: https://orcid.org/0000-0003-3104-2265)
- M. Fevzi Esen (ORCID: https://orcid.org/0000-0001-7823-0883)
- Esra Güzel (ORCID: https://orcid.org/0000-0002-0909-8935)
- Kadriye Nur Çakmur (ORCID: https://orcid.org/0009-0000-4666-0061)
- Feyzahan Uzun
Institutions
- University of Health Science (KH)
- Bakırköy Psychiatric Hospital (TR)
- Istanbul University-Cerrahpaşa (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Genes
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3390/genes16121471
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00