GNAQ inhibits tumorigenesis via the ARHGEF25-mediated RHOA pathway in NK/T-cell lymphoma
In summary, RHOA is a critical downstream effector of GNAQ in NKTCL. GNAQ promotes RHOA activation through ARHGEF25, which in turn regulates cellular functions by modulating cell proliferation and apoptosis, thereby influencing the progression of NKTCL.
Authors
- Zihe Zhang (ORCID: https://orcid.org/0000-0003-0197-2349)
- Yue Song (ORCID: https://orcid.org/0000-0003-0898-5281)
- Zhaoming Li (ORCID: https://orcid.org/0000-0002-2876-5182)
- Wenting Song (ORCID: https://orcid.org/0000-0003-0608-5298)
- Mingzhi Zhang (ORCID: https://orcid.org/0000-0003-3581-551X)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4105-0824)
- Hongwen Li (ORCID: https://orcid.org/0000-0003-0316-6500)
- Yuyang Gao
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1080/15384047.2025.2598074
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00