Development, validation, and application of an innovative UHPLC-Orbitrap-HRMS method for multi-class analysis of endocrine disruptors in bottled water: Influence of bottle material, water source, and retail price

This study presents a robust method for multi-class EDC analysis in bottled drinking water, offering high sensitivity and broad coverage, including EU watch list substances. Using an extensive suspect screening database from international inventories, it is the first Belgian study to map diverse EDCs in popular bottled water brands. The findings provide crucial data for public health risk assessment and inform regulatory and commercial decisions, emphasizing packaging, source type, and retail price as key factors.