Dose-Response Relationship of Niclosamide and Metformin Combination in Apc <sup>Min/+</sup> Mice: An Integrated <i>In Vivo</i> and Pharmacokinetic Modeling Study
By integrating <i>in vivo</i> efficacy testing with quantitative modeling, our study identified the 100 mg/kg combination of niclosamide and metformin as the optimal dose for chemoprevention in a murine FAP model, providing a strong rationale for future clinical translation in FAP management.
Authors
- Yoojeong Seo (ORCID: https://orcid.org/0000-0001-7243-5386)
- Joyeon Kang (ORCID: https://orcid.org/0000-0002-0256-7727)
- Jongwook Yu (ORCID: https://orcid.org/0000-0001-7489-2222)
- Jae Hee Cheon (ORCID: https://orcid.org/0000-0002-2282-8904)
- Tae Il Kim (ORCID: https://orcid.org/0000-0003-4807-890X)
- Jihye Park (ORCID: https://orcid.org/0000-0002-5836-8735)
- Jae Jun Park (ORCID: https://orcid.org/0000-0001-9974-1658)
- Soo Jung Park (ORCID: https://orcid.org/0000-0003-0699-6809)
- Dong-Keon Kim (ORCID: https://orcid.org/0000-0002-2641-2009)
- H. Lee (ORCID: https://orcid.org/0009-0008-6509-6812)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
Publication Details
- Journal
- Gut and Liver
- Published
- 2025-12-09
- DOI
- https://doi.org/10.5009/gnl250294
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00