Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

This retrospective study found that low-dose rivaroxaban was not significantly different from the standard dose in terms of thromboembolic events, bleeding, and all-cause mortality in elderly patients with NVAF. Although the safety profiles appeared similar between the two groups, the standard dose was associated with a higher cumulative survival rate in the unadjusted analysis. However, this observed survival difference may be influenced by baseline confounders, such as age and bleeding history. These findings suggest an association and support the need for further investigation into flexible anticoagulation strategies in clinical practice. Age, bleeding history, and renal function must be carefully considered when individualizing treatment.