Stability of caffeine citrate intravenous dilutions in sodium chloride and glucose solutions
Caffeine citrate diluted in 0.9% w/v sodium chloride or 5% w/v glucose is chemically stable at concentrations of 1 mg/mL and 12.5 mg/mL for up to 48 hours when stored at room temperature, meeting ICH and USP acceptance criteria in all cases. Caffeine citrate solutions did not meet the USP±10% criterion if stored at 8°C for 24 hours.
Authors
- Joanna Sobiak (ORCID: https://orcid.org/0000-0002-2764-1575)
- János Kerner (ORCID: https://orcid.org/0009-0007-3349-1685)
- Marta Karaźniewicz‐Łada (ORCID: https://orcid.org/0000-0003-4091-7035)
- Grzegorz Szynkaruk
- Marta Puchalska
Institutions
- Poznan University of Medical Sciences (PL)
Publication Details
- Journal
- European Journal of Hospital Pharmacy
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1136/ejhpharm-2025-004706
- Primary Topic
- Safe Handling of Antineoplastic Drugs
- Type
- article
- Field-Weighted Citation Impact
- 0.00