ENT1 inhibition enhances weight control and metabolic health in diet-induced obesity
EOS-518 promotes weight loss, improves metabolic parameters, restores adipose tissue function, and reduces inflammation in DIO mice. Altogether, this study positions ENT1 as a promising therapeutic target for the treatment of obesity and associated metabolic disorders.
Authors
- Laura Saerens
- Nicolas Rosewick (ORCID: https://orcid.org/0000-0002-4443-2492)
- Marie-Claire Letellier
- Anne-Catherine Michaux
- Julie Preillon
- Michael Deligny
- Alizée Canevat
- João Marchante (ORCID: https://orcid.org/0000-0001-7054-6859)
- Francesco Strozzi (ORCID: https://orcid.org/0000-0002-6845-6982)
- Lucas Martins Chaible (ORCID: https://orcid.org/0000-0002-9645-2663)
- Alexander Pfeifer (ORCID: https://orcid.org/0000-0001-8805-6831)
- Charlotte Philippart
- Steven Van der Plas
- Julie Chesné (ORCID: https://orcid.org/0000-0001-8831-4386)
- Yuko McGrath (ORCID: https://orcid.org/0009-0001-6204-4186)
- Reece Marillier
- Erica Houthuys (ORCID: https://orcid.org/0009-0001-5476-9486)
- David Carbonez (ORCID: https://orcid.org/0009-0003-3276-8153)
- Alexis Goffaux
- Dimitri Kondratow
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- Bone Therapeutics (BE)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.biopha.2025.118848
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00