Proteomics mediates the effects of biological aging on the progression of cardio-renal-metabolic comorbidity: a UK biobank cohort study
Biological aging was strongly associated with the progression of CRM comorbidity, and these associations were partly accounted for by specific circulating proteins. These findings highlight the potential of aging-centered strategies and proteomic biomarkers for improving the risk prediction of CRM health and identifying therapeutic targets.
Authors
- Kaiyang Lin (ORCID: https://orcid.org/0000-0003-1421-2728)
- Changxi Wang (ORCID: https://orcid.org/0000-0002-8299-6395)
- Zhennan Lin (ORCID: https://orcid.org/0000-0003-3602-7881)
- Yansong Guo (ORCID: https://orcid.org/0000-0003-0142-2160)
- Zhijie Lin (ORCID: https://orcid.org/0000-0001-6890-1225)
Institutions
- Fujian Medical University (CN)
- Fuyao Group (China) (CN)
- Education Department of Fujian Province (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12933-025-03035-6
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00