Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia
Future research on the identified dysfunctional molecular pathways may facilitate discovery of novel therapeutic targets for PDD. Diagnostic biomarker potential of the derived multiplex RNA biomarker assays should be investigated by larger clinical studies.
Authors
- Holly Green (ORCID: https://orcid.org/0000-0002-7977-6949)
- Fatma Büşra Işık (ORCID: https://orcid.org/0009-0009-3237-3120)
- Zubair Ahmed Nizamudeen (ORCID: https://orcid.org/0000-0002-5552-3656)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- Per Svenningsson (ORCID: https://orcid.org/0000-0001-6727-3802)
- Shirlee Tan (ORCID: https://orcid.org/0000-0001-8570-1209)
- Abdul Hye (ORCID: https://orcid.org/0000-0003-2237-4823)
- Grazziela Patrocinio Figueredo (ORCID: https://orcid.org/0000-0003-4094-7680)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Anto P. Rajkumar (ORCID: https://orcid.org/0000-0003-3203-6326)
- Richard Killick (ORCID: https://orcid.org/0000-0002-8815-3436)
Institutions
- University of Nottingham (GB)
- King's College London (GB)
- University of Exeter (GB)
- Institute of Mental Health (GB)
- Heavitree Hospital (GB)
- BioClinicum (Russia) (RU)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.parkreldis.2025.108150
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61