An Atypical Case of Lactobacillus jensenii Discitis and Osteomyelitis

<i>Lactobacillus</i>species are generally considered beneficial and are not typically pathogenic in humans. Bloodstream and tissue infections are uncommon and usually occur in immunocompromised patients. We present a case of a 63-year-old female with <i>Lactobacillus jensenii</i> lumbosacral discitis and osteomyelitis, complicated by small bilateral psoas abscesses and myositis. L4-L5 lumbar biopsy confirmed the presence of <i>L. jensenii</i> via next-generation sequencing after conventional tissue and blood cultures were negative. The presumed etiology of this infection was a genitourinary source. The patient received piperacillin-tazobactam for six weeks, followed by a transition to amoxicillin-clavulanate as a consolidative regimen, completing a roughly two-month antimicrobial course. Her symptoms, including gait instability and recurrent falls, resolved satisfactorily, with no concerning recurrence after discontinuation of antibiotics.