Stereoselective Synthesis of Protected 12‐Membered Macrolide Antibiotic 13 <i>E</i> ‐Disciformycin B Aglycone
A stereoselective synthesis of protected macrocyclic lactone core structure of 13 E ‐disciformycin B was accomplished in a convergent fashion employing commercially available (4 S ,5 S )‐2,2‐dimethyl‐1,3‐dioxolane‐4,5‐dicarboxylate, tiglic aldehyde and ( R )‐Roche ester. Key transformations include an Aldol reaction, CBS reduction, Takai olefination, Julia olefination, Nozaki–Hiyama–Kishi (NHK) reaction, and Yamaguchi esterification reaction.
Authors
- Naresh Gantasala (ORCID: https://orcid.org/0000-0002-0472-0369)
- Srihari Pabbaraja (ORCID: https://orcid.org/0000-0002-1708-6539)
- Sankara Rao Patta
Institutions
- University of Minnesota (US)
- Innovative Design Labs (United States) (US)
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1002/ejoc.202500950
- Primary Topic
- Synthetic Organic Chemistry Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00