Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression
C. sinensis can effectively promote the pathogenesis of CCA and significantly increase the expression of CCA-related genes (e.g., CK19 and CK7). The inflammation, disrupting circadian rhythms and altering energy metabolism caused by C. sinensis infection, may promote the progression of CCA. This study provides a foundational experimental basis for diagnosing and intervening in C. sinensis-related CCA.
Authors
- Deping Li
- Yuhong Wu (ORCID: https://orcid.org/0009-0001-5822-9882)
- Zeli Tang (ORCID: https://orcid.org/0000-0002-2436-0655)
- Shitao Li (ORCID: https://orcid.org/0000-0002-1398-8519)
- Ganzhen Deng (ORCID: https://orcid.org/0000-0003-0813-927X)
- Lixia Zeng
- Yu Chen (ORCID: https://orcid.org/0000-0002-1235-4645)
- Jun Kawanokuchi
- Yiqi Jiang (ORCID: https://orcid.org/0009-0002-3294-0366)
- Dengyu Liu (ORCID: https://orcid.org/0000-0002-8245-9573)
- Ning Ma
- Xueling Deng
- Tingzheng Zhan (ORCID: https://orcid.org/0000-0002-3309-9321)
Institutions
- Guangxi Medical University (CN)
- Suzuka University of Medical Science (JP)
- Chinese Center For Disease Control and Prevention (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s13071-025-07183-2
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00