Editorial: Ferroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatment

The field of ferroptosis research has burgeoned over the past decade, revealing profound implications for cancer biology and therapy. This special issue, "Ferroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatment," compiles pioneering work elucidating the multifaceted roles of ferroptosis across diverse malignancies. This topic that has rapidly evolved to reveal critical insights for cancer progression and therapy. This collection of nine articles underscores how ferroptosis-an iron-dependent form of cell death driven by lipid peroxidation-serves as a pivotal regulator in oncology, bridging molecular mechanisms with clinical applications. Collectively, these studies demonstrate that targeting ferroptosis can disrupt cancer resilience, yet they also emphasize the complexity of its interactions with immune cells and therapeutic agents, setting the stage for transformative advances in precision medicine. Innovations in nanomedicine and AI-driven delivery hold promise for optimizing combination therapies, ultimately transforming ferroptosis modulation into a cornerstone of oncology. This special issue collectively affirms that harnessing ferroptosis within the tumor immune microenvironment offers a paradigm for improving cancer treatment, with the potential to redefine therapeutic landscapes through continued interdisciplinary collaboration.