Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity
We found distinct pattern of STAT proteins phosphorylation associated with circulating immune cells in RA samples compared to healthy controls. These findings correlated with measures of disease activity. Analysis of phosphorylation patterns may be useful to understand disease pathology, and also as a marker of treatment response and disease outcome. By avoiding cell isolation, phosphorylation patterns in several cell subpopulation can be analyzed close to the <i>in vivo</i> cell profile.
Authors
- Devy Zisman (ORCID: https://orcid.org/0000-0003-0523-2292)
- Kara L. Davis (ORCID: https://orcid.org/0000-0002-7182-2592)
- Claudia Macaubas (ORCID: https://orcid.org/0000-0002-5472-8086)
- Elizabeth Mellins (ORCID: https://orcid.org/0000-0003-2577-139X)
- Mary C. Nakamura (ORCID: https://orcid.org/0000-0001-8127-9426)
- Astraea Jager
- Batuhan Bayram
- Jonathan Graf (ORCID: https://orcid.org/0000-0001-5204-9015)
- Noor Hussein (ORCID: https://orcid.org/0000-0003-2270-7739)
Institutions
- Technion – Israel Institute of Technology (IL)
- University of California, San Francisco (US)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Carmel Medical Center (IL)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fmed.2025.1622537
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis Foundation
- Pfizer
- University of California, San Francisco