Effects of zibotentan and dapagliflozin combined in patients with compensated cirrhosis: A randomized placebo‐controlled exploratory study
Combined zibo/dapa was well tolerated and had a good safety profile in patients with compensated cirrhosis, but had no conclusive effect on HVPG.
Authors
- Mattias Mandorfer (ORCID: https://orcid.org/0000-0003-2330-0017)
- Juan Carlos García‐Pagán (ORCID: https://orcid.org/0000-0001-9032-4954)
- Jaime Bosch (ORCID: https://orcid.org/0000-0003-3414-0055)
- Paweł Petryszyn (ORCID: https://orcid.org/0000-0003-2397-7028)
- José Ignacio Fortea (ORCID: https://orcid.org/0000-0001-5255-9445)
- Edilmar Alvarado‐Tápias (ORCID: https://orcid.org/0000-0003-2036-6133)
- Phil Ambery (ORCID: https://orcid.org/0000-0003-2978-1886)
- Niklas Berglind
- Marco Berning
- Don C. Rockey (ORCID: https://orcid.org/0000-0002-3751-2961)
- Annalisa Berzigotti (ORCID: https://orcid.org/0000-0003-4562-9016)
- Agustı́n Albillos (ORCID: https://orcid.org/0000-0001-9131-2592)
- Andrea De Gottardi (ORCID: https://orcid.org/0000-0002-4401-2340)
- Jan Oscarsson (ORCID: https://orcid.org/0000-0002-4573-517X)
- Kevin Persson
- Anne‐Kristina Mercier (ORCID: https://orcid.org/0009-0005-0915-5070)
- Jörn M. Schattenberg (ORCID: https://orcid.org/0000-0002-4224-4703)
- Min Lin (ORCID: https://orcid.org/0009-0009-4943-7610)
- Emilia Henricson
- Lise Lotte Gluud (ORCID: https://orcid.org/0000-0002-9462-4468)
Institutions
- University of Bern (CH)
- Universitat Autònoma de Barcelona (ES)
- Medical University of South Carolina (US)
- University of South Carolina (US)
- Instituto Cajal (ES)
- University Hospital of Bern (CH)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Wroclaw Medical University (PL)
- Marqués de Valdecilla University Hospital (ES)
- AstraZeneca (Netherlands) (NL)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Luzerner Kantonsspital (CH)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- AstraZeneca (Poland) (PL)
- AstraZeneca (Finland) (FI)
- AstraZeneca (Italy) (IT)
- AstraZeneca (Sweden) (SE)
- AstraZeneca (Spain) (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Medical University of Vienna (AT)
- Technische Universität Dresden (DE)
- Saarland University (DE)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1002/bcp.70332
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00