Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis
The findings suggest that the therapeutic effectiveness of TXA varies by the severity of brain injury. Post-injury administration of TXA significantly reduced 28-day mortality in patients with mild to moderate TBI (GCS: 9-15) but showed no benefit in patients with severe TBI (GCS: 3-8). Further research is needed to investigate the effect of TXA on thromboembolic events and to determine optimal dosing strategies, particularly for severe TBI patients.
Authors
- Ping Zhou (ORCID: https://orcid.org/0000-0001-9874-2659)
- Lu Ding (ORCID: https://orcid.org/0000-0001-7547-2844)
- Yanxun Lu (ORCID: https://orcid.org/0009-0003-5414-6531)
- Ziqi Wang (ORCID: https://orcid.org/0000-0001-7176-2369)
- Jiancheng Zhang (ORCID: https://orcid.org/0000-0002-2820-0851)
- K Yan
- Miao Qi
- Wentao Bian (ORCID: https://orcid.org/0009-0003-2085-9488)
Institutions
- Zhejiang Chinese Medical University (CN)
- The University of Sydney (AU)
- University of Electronic Science and Technology of China (CN)
- Sun Yat-sen University (CN)
- Northwest University (CN)
- Cooperative Trials Group for Neuro-Oncology (AU)
- Shaanxi Provincial People's Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fphar.2025.1677936
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00