Multiomics analysis demonstrated that TOPBP1 interacting checkpoint and Replication Regulator may serve as an immune-related biomarker indicative of poor prognosis in lung adenocarcinoma
TICRR functions as a critical oncogenic driver in LUAD, promoting proliferation, invasion, and immune evasion. Targeting TICRR may represent a novel strategy for personalized treatment of LUAD.
Authors
- Chengbin Lin
- Hongyan Yu
- Ziyi Chen (ORCID: https://orcid.org/0009-0005-5847-5011)
- Jinxian He
- Long He (ORCID: https://orcid.org/0000-0002-8494-8258)
- Gaofeng Liang (ORCID: https://orcid.org/0000-0003-0097-0296)
- Wenbin Song
- Keyun Zhu
- Cangchang Shi
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1740279
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00