Identification of subtypes and construction of a predictive model for novel subtypes in severe community-acquired pneumonia based on clinical metagenomics: a multicenter, retrospective cohort study
This study identified novel clinical subtypes of sCAP based on mNGS-derived microbiome characteristics. This approach exhibits superior performance in identifying high-risk sCAP patients, facilitating precise subtyping.
Authors
- Hanzhi Dai (ORCID: https://orcid.org/0009-0006-9228-5163)
- Yinghe Xu (ORCID: https://orcid.org/0000-0001-8863-7505)
- Ye Zheng (ORCID: https://orcid.org/0000-0002-8806-2761)
- Rongbin Qi
- Yongpo Jiang (ORCID: https://orcid.org/0000-0002-5681-3663)
- S. X. Li (ORCID: https://orcid.org/0000-0003-1503-7351)
- Shengwei Jin (ORCID: https://orcid.org/0000-0002-4734-8114)
- Ruihai Zhang (ORCID: https://orcid.org/0009-0004-9374-3432)
- Dongqing Lv (ORCID: https://orcid.org/0000-0001-8226-9596)
- Hang Xu (ORCID: https://orcid.org/0000-0003-4176-0738)
- Xiaomai Wu (ORCID: https://orcid.org/0000-0002-1382-5234)
- Ziyi Wang (ORCID: https://orcid.org/0000-0001-8174-0593)
- Yingying Yu (ORCID: https://orcid.org/0000-0002-9452-0298)
- Xiaoyan Lu (ORCID: https://orcid.org/0000-0002-5592-7239)
- Changlin Xu (ORCID: https://orcid.org/0009-0002-8375-6833)
- Shi‐Yi Chen (ORCID: https://orcid.org/0009-0006-7647-399X)
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Zhejiang Taizhou Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1676502
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province