Shaoyao Gancao decoction alleviates functional constipation by inhibiting Escherichia-Shigella expansion, modulating gut microbiota, and suppressing dysbiosis-induced endocannabinoid production: evidence from a self-controlled pilot study
These findings suggest that SGD alleviates FC by restoring microbial balance, enhancing SCFA production, and suppressing dysbiosis-induced endocannabinoid signaling. As a pilot study, the results are preliminary but provide mechanistic insights that warrant validation in larger, randomized controlled trials.
Authors
- Qing Li (ORCID: https://orcid.org/0009-0003-6263-6055)
- Zhihui Huang (ORCID: https://orcid.org/0000-0001-9910-0228)
- Xiaoqiong Li (ORCID: https://orcid.org/0000-0001-5379-2943)
- Yang Wang (ORCID: https://orcid.org/0000-0003-0447-3107)
- Chengbin Wang (ORCID: https://orcid.org/0000-0002-6535-5967)
- Hua Gao (ORCID: https://orcid.org/0000-0002-9698-5830)
- Jinjun Li (ORCID: https://orcid.org/0000-0003-4662-7207)
- Liying Zhu
- Jinshan Nie
Institutions
- Sir Run Run Shaw Hospital (CN)
- Soochow University (CN)
- Taixing People's Hospital (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- Taizhou First People's Hospital (CN)
- Suzhou Chien-Shiung Institute of Technology (CN)
- Baotou Medical College (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1705271
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Junta de Castilla y León