B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies

These studies highlight a regulatory role for B-1 cells in shaping adaptive immune tolerance in the Lyn-/- lupus model.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-12-09
DOI
https://doi.org/10.3389/fimmu.2025.1721021
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.00

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article

B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies

Anne B. Satterthwaite, Kristina Ottens
Frontiers in Immunology
T-cell and B-cell Immunology
article

B-1 cells contribute to increased total IgM and shape IgG autoreactivity profiles in Lyn-/- mice but are not a major source of lupus-associated pathogenic autoantibodies

Anne B. Satterthwaite, Kristina Ottens
article en

Abstract

These studies highlight a regulatory role for B-1 cells in shaping adaptive immune tolerance in the Lyn-/- lupus model.

Frontiers in ImmunologyVol. 16
Southwestern Medical Center (US), The University of Texas Southwestern Medical Center (US)
Rheumatology Research Foundation, National Institutes of Health
Openalex Percentile: Top 55%
T-cell and B-cell Immunology
DOIOpen Access PDFOpenAlex
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