Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection
Low <i>TLR7</i> levels were associated with severe COVID-19, and together with <i>OAS1</i> expression were modulated over time according to severity. While <i>TLR7</i> expression decreased across all severity groups as the disease resolved, <i>OAS1</i> expression persisted in severe cases with higher viremia.
Authors
- Isidoro González‐Álvaro (ORCID: https://orcid.org/0000-0001-9614-5199)
- Sara Fernández de Córdoba‐Oñate (ORCID: https://orcid.org/0009-0004-5686-3486)
- Elena Fernández‐Ruiz (ORCID: https://orcid.org/0000-0001-5380-1686)
- Ana Marcos‐Jiménez (ORCID: https://orcid.org/0000-0002-7606-3580)
- Estíbaliz Alegría‐Carrasco (ORCID: https://orcid.org/0000-0001-7119-4920)
- Marta Jaén (ORCID: https://orcid.org/0000-0002-2088-8807)
- Emilia Roy‐Vallejo
- Núria Montés (ORCID: https://orcid.org/0000-0001-9526-2772)
- Pablo Delgado‐Wicke (ORCID: https://orcid.org/0000-0003-3988-3704)
- Nelly Daniela Zurita Cruz (ORCID: https://orcid.org/0000-0002-3679-4709)
- Rosa Carracedo-Rodríguez
- Ana Nicolao-Gómez
- Laura Cardeñoso-Domingo
Institutions
- Universidad San Pablo CEU (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitario de La Princesa (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1713928
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- European Commission
- Instituto de Salud Carlos III
- European Regional Development Fund