Structured implementation of a bubble-CPAP program to reduce bronchopulmonary dysplasia in preterm infants
Bronchopulmonary dysplasia (BPD) remains a major complication in premature infants, affecting approximately 40% of infants born under 1000 grams. While RCTs showed only modest benefit of early CPAP, observational studies reported greater improvements, underscoring the importance of consistent implementation beyond initial use. Structured stepwise implementation of the b-CPAP program was associated with improved survival without BPD and reduced BPD prevalence. The findings may inform future strategies to enhance reproducibility and effectiveness of CPAP use through systematic implementation.
Authors
- Jalal M. Abu‐Shaweesh
- Tina DiFiore (ORCID: https://orcid.org/0000-0002-8634-4925)
- Sabine Iben
- Carol Bennett (ORCID: https://orcid.org/0000-0002-3033-9860)
- Julie Gamary
- Vanishree Nandakumar
- Firas Saker
- Ceyda Acun (ORCID: https://orcid.org/0000-0002-9924-1343)
- Subhash Puthuraya (ORCID: https://orcid.org/0000-0001-9616-9115)
- Hany Aziz
- Amanda J. Sheppard (ORCID: https://orcid.org/0000-0001-5240-2704)
- Hany Aly (ORCID: https://orcid.org/0000-0001-7395-6394)
- Mohamed A. Mohamed (ORCID: https://orcid.org/0000-0003-3844-8807)
- Hatem Eltaly (ORCID: https://orcid.org/0009-0000-9934-3887)
- John G. Dickson
- Tetyana Nesterenko
- Kelly Yuhasz
- Laura Bobek
Institutions
- Cleveland Clinic (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1038/s41390-025-04635-4
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00