Lyg1 deficiency aggravated LPS-induced chronic epididymal inflammation and sperm dysfunction in mouse
LYG1 regulates the balance between epididymal inflammation and tissue repair. Its deficiency aggravates LPS-induced epididymal fibrosis and sperm dysfunction. This study identifies LYG1-dependent pathways as potential therapeutic targets for chronic epididymitis-related infertility.
Authors
- Xuexia Liu (ORCID: https://orcid.org/0000-0002-1991-4473)
- Bin Gong (ORCID: https://orcid.org/0000-0002-9464-3423)
- Jia Wei (ORCID: https://orcid.org/0000-0003-3024-8878)
- Fujun Liu (ORCID: https://orcid.org/0000-0001-6708-207X)
- Xi‐Lin Wang (ORCID: https://orcid.org/0000-0002-3990-6454)
- Yunhai Zhang (ORCID: https://orcid.org/0000-0001-9721-5910)
Institutions
- Weifang Medical University (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1699581
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00