Canustatins A and B, Two Polyketides from <i>Streptomyces canus</i> NA07887
Canustatins A and B, two structurally novel polyketide metabolites, were isolated from the actinobacterium <i>Streptomyces canus</i> NA07887. Their structures were determined through comprehensive spectroscopic analysis, including NMR and HRESIMS, combined with the comparison of experimental and theoretical electronic circular dichroism (ECD) spectra. Canustatin A features an unprecedented 3,6-dioxabicyclo[3.1.0]hexane moiety, a structural motif rarely encountered in type I polyketides. Stable isotope labeling studies facilitated the proposal of a plausible biosynthetic pathway for these compounds. In addition, canustatin A exhibited moderate antibacterial activity against multidrug-resistant <i>Acinetobacter baumannii</i> ATCC AYE.
Authors
- Fang Zhou Yin
- Hui Ming Ge (ORCID: https://orcid.org/0000-0002-0468-808X)
- Jing Shi (ORCID: https://orcid.org/0000-0001-9389-4055)
- Renxiang Tan (ORCID: https://orcid.org/0000-0001-6532-6261)
- Zhong‐Ping Jiang (ORCID: https://orcid.org/0000-0002-4868-9359)
- Hao Guo (ORCID: https://orcid.org/0009-0002-9390-9354)
- X. Wang
- Zhang Yuan Yan
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04564
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79