Effectiveness of preimplantation genetic testing for aneuploidy in improving clinical and neonatal outcomes for patients with recurrent pregnancy loss

PGT-A can significantly improve CPR and LBR in patients with RPL aged < 38 years with a history of three miscarriages, a normal chromosomal karyotype, and a normal ovarian reserve. For patients with a history of two miscarriages, PGT-A notably enhances a success of clinical pregnancy conversion into live birth. However, for individuals with diminished ovarian reserve, chromosomal polymorphisms, or a history of four or more miscarriages, a cautious and individualized assessment is necessary.