Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target
Our findings demonstrate that the elevated MFI of HLA-DR <i>on CD14+</i> and <i>CD14+ CD16- monocyte</i> is associated with DN and is significantly associated with worsened renal function, highlighting monocyte HLA-DR as a key immune mediator in DN progression and a promising therapeutic target for intervention.
Authors
- Shaojie Fu (ORCID: https://orcid.org/0000-0001-9107-1063)
- Sensen Su
- Zhonggao Xu (ORCID: https://orcid.org/0000-0001-9278-4532)
- Yue Wang (ORCID: https://orcid.org/0000-0001-7883-0934)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3389/fendo.2025.1733139
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation