Microbial production of short-chain fatty acids attenuates long-term neurologic impairment after traumatic brain injury
Diet-facilitated microbial production of acetate and butyrate attenuates behavioral deficits of LTNI after TBI and produces enduring benefits at the single-cell level on the neuro-inflammatory and neuro-progenitor responses. This therapeutic approach could have a broader potential to prevent neurodegenerative disease.
Authors
- Eliana Mariño (ORCID: https://orcid.org/0000-0001-5371-8778)
- Gary Kohanbash (ORCID: https://orcid.org/0000-0002-3953-8022)
- Bryan Dodson
- Ruchira Menka Jha (ORCID: https://orcid.org/0000-0002-3047-7649)
- Dennis Simon (ORCID: https://orcid.org/0000-0002-3824-2326)
- Itay Raphael (ORCID: https://orcid.org/0000-0002-7369-2752)
- Dhivyaa Rajasundaram (ORCID: https://orcid.org/0000-0001-7417-8002)
- Matthew B. Rogers (ORCID: https://orcid.org/0000-0002-4958-8971)
- Michael J. Morowitz (ORCID: https://orcid.org/0000-0001-8172-637X)
- Keri Janesko‐Feldman (ORCID: https://orcid.org/0000-0003-3970-3013)
- Patrick M. Kochanek (ORCID: https://orcid.org/0000-0002-2627-913X)
- Zujian Xiong (ORCID: https://orcid.org/0000-0003-2943-1931)
- Chaim T. Sneiderman
- Xuejun Li (ORCID: https://orcid.org/0000-0001-6406-4423)
- Robert S. B. Clark
- Mioara D. Manole
- Vincent Vagni
Institutions
- Barrow Neurological Institute (US)
- Central South University (CN)
- University of Pittsburgh (US)
- Discovery Institute (US)
- UPMC Health System (US)
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- Neurological Surgery (US)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12974-025-03615-z
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00