Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
For future therapeutic trials, selecting PwPD with moderate, quantifiable FOG and utilizing appropriate outcome measures like %FT will improve the ability to identify intervention effects. Even for short trials, analyses must account for gait decline. An FOG outcome measure that requires less analysis time burden than video quantification, and the ability for at-home monitoring is needed.
Authors
- Mitesh Lotia
- Aliyah Glover (ORCID: https://orcid.org/0000-0002-3872-6902)
- Lakshmi Pillai (ORCID: https://orcid.org/0000-0002-6570-2041)
- Reid D. Landes (ORCID: https://orcid.org/0000-0002-6349-0081)
- Edgar García‐Rill (ORCID: https://orcid.org/0000-0003-1367-3071)
- Shannon Doerhoff
- Tuhin Virmani (ORCID: https://orcid.org/0000-0002-1826-2020)
- Rohit Dhall (ORCID: https://orcid.org/0000-0001-9436-1920)
- Jennifer Sue Kleiner
Institutions
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1002/acn3.70276
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Arkansas for Medical Sciences
- Parkinson's Foundation
- National Institute of General Medical Sciences