A Case of <scp>AL</scp> Amyloidosis With Hepatomegaly as the Main Clinical Manifestation
Light chain (AL) amyloidosis presenting predominantly with hepatomegaly is a rare and frequently misdiagnosed condition. While clinical features are non-specific, elevated ALP/GGT should raise suspicion. A liver biopsy remains the gold standard for diagnosis. Although there is no disease-specific therapy for hepatic amyloidosis, timely chemotherapy initiation-particularly monoclonal antibody-based regimens-can significantly improve prognosis and lead to symptom resolution.
Authors
- Mingfeng Zhao (ORCID: https://orcid.org/0009-0006-2503-6677)
- Guoling Gao
- Renjun Lv (ORCID: https://orcid.org/0000-0002-6530-8386)
- Xingbin Ma (ORCID: https://orcid.org/0000-0003-2874-8312)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9138-9052)
- Shuchen Dong (ORCID: https://orcid.org/0009-0008-1771-5666)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/ccr3.71640
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00