Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives
Ceftolozane/tazobactam resistance development was associated mainly with chromosomal mutations in the ampC gene but also with mutations in its regulatory genes. Knowledge about these mutations and gene polymorphisms is essential for interpreting resistance phenotypes from genomic data.
Authors
- Marin Lahouati (ORCID: https://orcid.org/0000-0003-0043-7336)
- Laure Coulange-Mayonnove
- Cécile Bébéar (ORCID: https://orcid.org/0000-0001-6065-2332)
- Raoudha Grami
- Ulysse Guyet (ORCID: https://orcid.org/0000-0002-3603-5382)
- Léa Bientz (ORCID: https://orcid.org/0009-0005-4097-7355)
- Sabine Aillerie
- Véronique Dubois (ORCID: https://orcid.org/0000-0002-9484-9747)
- Macha Nikolski (ORCID: https://orcid.org/0000-0001-6059-577X)
- Alexis Groppi (ORCID: https://orcid.org/0000-0002-3341-8281)
- André Augusto Franco Marques (ORCID: https://orcid.org/0000-0002-6682-944X)
- Melissande Hertzmann
- Hugo Boijout
- Audrey Toirot
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Bordeaux Population Health (FR)
- Institut de Biochimie et Génétique Cellulaires (FR)
- Institut Polytechnique de Bordeaux (FR)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12866-025-04517-z
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00