The molecular architecture of severe pediatric traumatic brain injury: integrated omics reveal therapeutic pathways
Despite the heterogeneity in injury mechanisms and clinical presentations, our findings reveal a convergent host response, characterized by shared transcriptomic and metabolic signatures across all time points. This convergence highlights potentially targetable biological pathways and opens the door to the development of novel therapeutic strategies for severe pediatric TBI.
Authors
- Ali Yılmaz (ORCID: https://orcid.org/0000-0002-7482-1712)
- Caleb Bupp (ORCID: https://orcid.org/0000-0003-4255-0396)
- Nicholas Hartog (ORCID: https://orcid.org/0000-0002-7614-0371)
- Jacob Charron
- Daniel Woldring (ORCID: https://orcid.org/0000-0001-8881-9931)
- Nadia Ashrafi
- Austin Goodyke (ORCID: https://orcid.org/0000-0003-3989-1026)
- Louis J. Sanfilippo
- Surender Rajasekaran (ORCID: https://orcid.org/0000-0002-4430-006X)
- Juozas Gordevičius
- Jeremy W. Prokop (ORCID: https://orcid.org/0000-0002-1818-9695)
- Stewart Francis Graham (ORCID: https://orcid.org/0000-0003-1001-0002)
- Khalid Abdullah
- Romana Ashrafi Mimi
- Elora Hussain
- Charitha Subrahmanya
- Karolis Krinickis
- Vilija Lomeikaite
- Emily Nonnemacher
- Annie Needs
- Kylie Maxton
Institutions
- Grand Rapids Community College (US)
- Van Andel Institute (US)
- Oakland University (US)
- Helen DeVos Children's Hospital (US)
- Royal Oak Community Coalition (US)
- Michigan State University (US)
Publication Details
- Journal
- Critical Care
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s13054-025-05789-7
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39