Slo1 Deficient Myoblast Exosomes‐Derived miR‐222‐3p Inhibits Osteogenic Differentiation via Targeting of STAT3
Slo1 deficiency in muscle results in decreased bone mass mediated by exosomal miR-222-3p. MiR-222-3p binds and inhibits the transcription of STAT3 to suppress the differentiation of osteoblasts. Slo1-silenced myoblasts-derived exosomal miR-222-3p inhibit osteogenesis and cause bone loss through the miR-222-3p/STAT3 pathway.
Authors
- Xinrun Ma
- Yanhong Gao (ORCID: https://orcid.org/0000-0003-4173-4855)
- Yunyi Jiang
- Xue Lei (ORCID: https://orcid.org/0000-0001-9647-3782)
- Jizhong Liu (ORCID: https://orcid.org/0000-0002-7658-5231)
- Rang Xu (ORCID: https://orcid.org/0000-0002-4841-1912)
- Yonghui Wang (ORCID: https://orcid.org/0000-0002-2588-6958)
- Yang Chen (ORCID: https://orcid.org/0000-0001-9406-8273)
- Chao Xia (ORCID: https://orcid.org/0000-0001-8207-6647)
Institutions
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jcsm.70115
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- Fundamental Research Funds for the Central Universities