Discovery of FBP1 as novel therapeutic target and asiatic acid-hydrogen sulfide donors accelerate diabetic wound healing
This study validates FBP1 targeting as a feasible strategy to address diabetic wound healing. It establishes AA-H<sub>2</sub>S donor derivatives, particularly AA4 acting via dual FBP1 targeting, as an encouraging precision therapy for diabetic wound healing.
Authors
- Fanxing Xu (ORCID: https://orcid.org/0000-0002-7835-8091)
- Dahong Li (ORCID: https://orcid.org/0000-0002-6964-4619)
- Huiming Hua (ORCID: https://orcid.org/0000-0002-0258-3647)
- Siqing Li (ORCID: https://orcid.org/0000-0001-8366-6032)
- Weirenbo Wang
- S. Wang (ORCID: https://orcid.org/0009-0005-1257-783X)
- Maosheng Cheng (ORCID: https://orcid.org/0000-0001-9073-4806)
- Dong Lin (ORCID: https://orcid.org/0000-0002-1196-2446)
- Chao Zheng (ORCID: https://orcid.org/0000-0001-9691-3573)
- Lu Shi (ORCID: https://orcid.org/0000-0002-1842-8334)
- Ye Tao (ORCID: https://orcid.org/0000-0002-8075-7323)
- Junxia Wu (ORCID: https://orcid.org/0000-0002-3620-959X)
- Sisi Ou
Institutions
- Shenyang Pharmaceutical University (CN)
- Centre for Addiction and Mental Health (CA)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.jare.2025.12.003
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 0.00