YAP/TEAD-activated TAG synthesis and peroxidation in lipid droplets confer ROS resistance in cancer stem cells
We demonstrate that TAG in peri-mitochondrial LDs functions as a ROS scavenger, enabling CSCs to survive in hyperoxidative environments. Targeting the signaling pathways involved in TAG synthesis presents a potential strategy for eradicating CSCs.
Authors
- Anna Fen‐Yau Li (ORCID: https://orcid.org/0009-0004-8597-0459)
- Shih‐Chieh Hung (ORCID: https://orcid.org/0000-0003-1813-4616)
- Jiun‐Han Lin
- Chen‐Chi Liu (ORCID: https://orcid.org/0000-0001-7626-289X)
- Han‐Shui Hsu (ORCID: https://orcid.org/0000-0002-4584-1626)
- Tien‐Wei Hsu (ORCID: https://orcid.org/0000-0003-4136-1251)
- Wei‐Chung Cheng (ORCID: https://orcid.org/0000-0002-1229-4857)
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
Institutions
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- Taipei Veterans General Hospital (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.redox.2025.103968
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00