Ambient temperature exposure on inflammatory blood proteins—A longitudinal self-sampling survey in young Swedish adults
The mechanisms by which temperature exposure affects health outcomes remain unclear. In this study, we conducted three repeated measurements (2020-2022) by collecting self-sampled volumetric dry blood spots (DBSs) from 807 participants from the Swedish BAMSE cohort (mean age 25.9 years). By estimating individual-address level daily temperature using a high-resolution spatiotemporal model, we found that 58 (16%) of the 365 studied inflammation-related proteins were significantly associated with short-term exposure to ambient temperatures. The impact of temperature exposure was modified by sex, smoking, asthma, and concurrent exposure to air pollution. The temperature-associated proteins were linked to lung function, blood pressure, and HbA1c with validations in the UK Biobank. Furthermore, peak temperature exposure (both cold and heat) was associated with significantly increased proteomic age acceleration. Our findings suggest that ambient temperature exposure may cause adverse health effects through perturbating inflammation-related proteins.
Authors
- Zhebin Yu (ORCID: https://orcid.org/0000-0001-9392-5624)
- Niclas Roxhed (ORCID: https://orcid.org/0000-0002-7147-6730)
- Göran Pershagen
- Tom Bellander (ORCID: https://orcid.org/0000-0001-7336-4161)
- Sophia Björkander (ORCID: https://orcid.org/0000-0002-4600-2883)
- Natalia Hernandez‐Pacheco (ORCID: https://orcid.org/0000-0002-6313-1847)
- Annika Bendes (ORCID: https://orcid.org/0000-0001-9329-2353)
- Jochen M. Schwenk (ORCID: https://orcid.org/0000-0001-8141-8449)
- Federica Nobile (ORCID: https://orcid.org/0000-0002-8040-8975)
- Massimo Stafoggia (ORCID: https://orcid.org/0000-0003-2843-2908)
- Petter Ljungman (ORCID: https://orcid.org/0000-0002-7815-2632)
- Maura Kere (ORCID: https://orcid.org/0000-0002-5725-2773)
- Anne‐Sophie Merritt (ORCID: https://orcid.org/0000-0002-4497-1779)
- Inger Kull (ORCID: https://orcid.org/0000-0001-6096-3771)
- Simon Kebede Merid (ORCID: https://orcid.org/0000-0001-5974-7676)
- Olena Gruzieva (ORCID: https://orcid.org/0000-0003-4147-5654)
- Shizhen He (ORCID: https://orcid.org/0000-0002-1674-0332)
- Susanna Klevebro (ORCID: https://orcid.org/0000-0002-1261-6502)
- Anna Bergström (ORCID: https://orcid.org/0000-0003-4084-2336)
- Jiawei Zhang (ORCID: https://orcid.org/0000-0003-4253-9015)
- Erik Melén
Institutions
- University of Copenhagen (DK)
- Karolinska University Hospital (SE)
- Stockholm University (SE)
- Science for Life Laboratory (SE)
- Danderyds sjukhus (SE)
- Karolinska Institutet (SE)
- ASL Roma (IT)
- Stockholm South General Hospital (SE)
- Sachs' Children and Youth Hospital (SE)
- Centre for Palaeogenetics (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- iScience
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.isci.2025.114383
- Citations
- 1
- Primary Topic
- Climate Change and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 1.20