Development and Characterization of a Tunable <scp>PDMS</scp> Substrate Model for Investigating Elastic Properties and Mechanical Stretching in Intervertebral Disc Cells
The PDMS-based stretching platform offers a biocompatible and tunable mechanical environment that mimics physiological and pathophysiological elastic properties. It enables systematic investigations on how elastic properties and mechanical strain modulate AF cell behavior in IVD disease progression. Finally, this study raises the awareness of non-uniform and transverse strain components within the stretching chambers and highlights the discrepancy of effective strain transfer to the cell interaction surface.
Authors
- Wolfgang Hitzl (ORCID: https://orcid.org/0000-0002-7696-1479)
- Karin Wuertz‐Kozak (ORCID: https://orcid.org/0000-0002-3281-4629)
- Vinay V. Abhyankar (ORCID: https://orcid.org/0000-0002-8462-3920)
- Kory Schimmelpfennig (ORCID: https://orcid.org/0000-0001-7392-6603)
- Christopher L. Lewis (ORCID: https://orcid.org/0000-0002-5728-9699)
- Mikkael Lamoca (ORCID: https://orcid.org/0000-0002-9218-3523)
- Johannes Hasler (ORCID: https://orcid.org/0009-0009-1581-2160)
- Rui Liu (ORCID: https://orcid.org/0000-0001-9928-5373)
- Shuhuan Zhang (ORCID: https://orcid.org/0009-0000-5952-291X)
- Sami Farajollahi
Institutions
- Rochester Institute of Technology (US)
- Paracelsus Medical University (AT)
- Schön Klinik München Harlaching (DE)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jsp2.70140
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47