Pan-cancer profiling links C1orf50 to DNA repair and immune modulation in ovarian cancer
The overexpression of C1orf50 characterizes an aggressive immunogenomic phenotype in ovarian cancer, distinguished by genomic instability, impaired DNA repair mechanisms, and extensive immunosuppression. These findings indicate that C1orf50 warrants consideration as a potential biomarker and a prospective target for therapeutic investigation. Furthermore, they advocate for the progression to prospective validation and functional studies to ascertain its clinical significance.
Authors
- Atsushi Tanaka (ORCID: https://orcid.org/0000-0003-1229-4539)
- Shinichi Toyooka (ORCID: https://orcid.org/0000-0002-7588-6745)
- Vicky Chin (ORCID: https://orcid.org/0000-0002-8908-1243)
- Atsushi Fujimura (ORCID: https://orcid.org/0000-0002-8638-5460)
- Seiji Arai (ORCID: https://orcid.org/0000-0002-9514-735X)
- Akira Ohtsu (ORCID: https://orcid.org/0009-0007-4757-4633)
- Tirso Peña
- Yusuke Otani
- Anna Rogachevskaya
Institutions
- Broad Institute (US)
- UMass Memorial Health Care (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Okayama University (JP)
- Gunma University (JP)
- Kagawa University (JP)
- UMass Memorial Medical Center (US)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s13048-025-01916-8
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00