Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger
The updated PECARN rule had high sensitivity but lower specificity for identifying febrile infants 28 days or younger with invasive bacterial infections in this study, with no missed cases of bacterial meningitis. These results may support shared decision-making regarding select vs routine use of lumbar puncture among infants classified as being at low risk of invasive bacterial infections.
Authors
- Thomas Waterfield (ORCID: https://orcid.org/0000-0001-9452-7716)
- Nathan Kuppermann (ORCID: https://orcid.org/0000-0002-7854-4943)
- Etimbuk Umana (ORCID: https://orcid.org/0000-0002-0780-8614)
- Jianling Xie (ORCID: https://orcid.org/0000-0002-0588-8016)
- Brett Burstein (ORCID: https://orcid.org/0000-0002-1107-9514)
Institutions
- Queen's University Belfast (GB)
- George Washington University Hospital (US)
- Children's National (US)
- University of Calgary (CA)
- George Washington University (US)
- Montreal Children's Hospital (CA)
- Royal Belfast Hospital for Sick Children (GB)
- McGill University Health Centre (CA)
Publication Details
- Journal
- JAMA
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1001/jama.2025.21454
- Citations
- 1
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.18