Immunogenicity of Adalimumab in Bacterial Molecular Mimicry: In Silico Analysis
This study represents a first step toward identifying a potential microbial factor driving antiadalimumab antibody formation. The predicted cross-reactive regions provide specific candidates for further in vitro validation to confirm molecular mimicry and refine epitope mapping. Understanding these mechanisms may ultimately inform the design of less immunogenic biologics and guide clinical strategies to predict and prevent antidrug antibody formation.
Authors
- Marlon Múnera (ORCID: https://orcid.org/0000-0003-3428-0541)
- Andrés Sánchez (ORCID: https://orcid.org/0000-0001-7460-3427)
- Óscar Correa-Jiménez (ORCID: https://orcid.org/0000-0001-6007-2821)
- Diana Isabel Pachón-Suárez (ORCID: https://orcid.org/0000-0003-3483-185X)
- Germán Mejía‐Salgado (ORCID: https://orcid.org/0000-0002-1241-0715)
- Alejandra de‐la‐Torre (ORCID: https://orcid.org/0000-0003-0684-1989)
Institutions
- Universidad Nacional de Colombia (CO)
- Corporación Universitaria Rafael Nuñez (CO)
- Universidad del Rosario (CO)
Publication Details
- Journal
- JMIR Bioinformatics and Biotechnology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.2196/83872
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00